Yes. Most peptides (Matrixyl, Argireline, multi-peptide blends) are fine with vitamin C in the same routine. The one combination to keep apart is copper peptides with strong L-ascorbic acid: use vitamin C in the morning and copper peptides at night.
Why copper peptides are the exception
Pure vitamin C (L-ascorbic acid) is acidic and reactive, and copper ions can oxidise it. Mixing the two in one step may make both less useful and can irritate. Splitting them between morning and night avoids the question entirely.
A simple routine
- Morning: cleanse, vitamin C serum, multi-peptide serum or peptide moisturizer, sunscreen.
- Night: cleanse, copper peptide or multi-peptide serum, moisturizer. On retinoid nights, keep peptides gentle and skip copper if your skin is reactive.
Layering order
Thinnest to thickest. Water-based vitamin C first, wait a minute, then your peptide serum, then moisturizer. Vitamin C derivatives (such as sodium ascorbyl phosphate) are gentler and less fussy about pairing.
Related guides
Not sure which peptide to start with? See peptides vs hyaluronic acid, best peptide serums and best peptide moisturizers.